SLC39A1

solute carrier family 39 member 1

Dependent Cell Lines

CRISPR: 12/789

RNAi: 4/708

Gene Effect

Dependent Cell Line:
A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Probability of Dependency:
Probabilities of dependency are calculated for each gene score in a cell line as the probability that score arises from the distribution of essential gene scores rather than nonessential gene scores. See here for details.
Gene Effect:
Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.


Enriched Lineages

CRISPR

Gene Effect (CERES)

1. Melanoma (4.9e-12) n=47
2. Skin (1.8e-10) n=54

RNAi

Gene Effect (DEMETER2)

1. Skin (9.5e-07) n=45
2. Melanoma (2.3e-06) n=42
3. NSCLC (3.0e-05) n=101

Enriched lineages have p-values < 0.0005 (shown in parentheses). n= indicates the number of cell lines plotted in that lineage.


Expression & CN

Expression


Copy Number log2(relative to ploidy + 1)

Expression:
RNASeq files are aligned with STAR and quantified with RSEM, then TPM-normalized. Reported values are log2(TPM+1).
Copy Number:
The relative copy number pipeline used varies by cell line. For around 1000 lines, Sanger WES data was used, while for around 700 lines, Broad WES data was used. The remaining lines use SNP array data as explained in 10.1038/s41586-019-1186-3. See 10.1101/720243 for details on how CN source is chosen per line. Lines with WES data were processed through GATK using PONs from TCGA without matched normals and transformed by log2(x+1).


Top Co-dependencies

CRISPR (Avana) Public 20Q3

GenePearson correlation
PlotSOCS30.33
PlotLIF0.33
PlotLIFR-0.26
PlotSOX100.24
PlotSTAT3-0.24

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotMAP1LC3A0.32
PlotGPAA10.29
PlotSEPTIN2-0.27
PlotATG12-0.27
PlotLY6K0.27

Target Tractability



Mutations

# of cell lines



Description

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Mutation Public 20Q3

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Fusion 20Q3

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Translocation

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Methylation (1kb upstream TSS) (1 153936117-153937117)

Methylation (1kb upstream TSS) (1 153940660-153941660)

Methylation (1kb upstream TSS) (1 153935968-153936968)

Methylation (1kb upstream TSS) (1 153935844-153936844)

CpG Methylation

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  • Official symbol: SLC39A1
  • Full name: solute carrier family 39 member 1
  • Location:
  • Also known as: ZIP1, ZIRTL
  • Entrez ID: 27173
  • Ensembl ID: ENSG00000143570

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