SLC7A1

solute carrier family 7 member 1

Dependent Cell Lines

CRISPR: 116/625 STRONGLY SELECTIVE

RNAi: 18/711 STRONGLY SELECTIVE

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Strongly Selective: A gene whose dependency is at least 100 times more likely to have been sampled from a skewed distribution than a normal distribution (i.e. skewed-LRT value > 100).


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Haematopoietic And Lymphoid (2.1e-11)
2. Solid (5.0e-11)
3. Lymphoma (3.3e-09)
4. AML (8.4e-07)
5. Leukemia (5.8e-05)
6. Neuroblastoma (2.5e-04)
7. Peripheral Nervous System (2.5e-04)
8. Central Nervous System (3.3e-04)

RNAi

Dependency Score (DEMETER2)

1. AML (8.7e-07)
2. Haematopoietic And Lymphoid (5.3e-06)
3. Leukemia (2.2e-04)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotTRPM70.47
PlotSLC7A50.43
PlotSLC3A20.40
PlotGART0.39
PlotMTHFD10.38

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotTMEM169-0.31
PlotGLS0.28
PlotUTP3-0.26
PlotUTP3-0.26
PlotNACAD0.26

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Fusion 19Q3

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Translocation

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Methylation (1kb upstream TSS) (13 30169825-30170825)

CpG Methylation

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  • Official symbol: SLC7A1
  • Full name: solute carrier family 7 member 1
  • Location:
  • Also known as: HCAT1, CAT-1, ERR, REC1L, ATRC1
  • Entrez ID: 6541
  • Ensembl ID: ENSG00000139514

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