SMARCA2

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2

Dependent Cell Lines

CRISPR: 24/625 STRONGLY SELECTIVE

RNAi: 30/710 STRONGLY SELECTIVE

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Strongly Selective: A gene whose dependency is at least 100 times more likely to have been sampled from a skewed distribution than a normal distribution (i.e. skewed-LRT value > 100).


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Lung Adenocarcinoma (1.6e-17)
2. Lung NSC (1.5e-14)
3. Lung (5.3e-14)

RNAi

Dependency Score (DEMETER2)

1. Lung Adenocarcinoma (5.5e-11)
2. Lung NSC (2.4e-09)
3. Lung (6.4e-09)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotCHD20.22
PlotSAXO10.22
PlotHMGXB40.22
PlotGFPT20.21
PlotCWF19L2-0.21

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotTEX2640.32
PlotANAPC150.31
PlotRNASE13-0.28
PlotUSP350.25
PlotARMH40.25

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Fusion 19Q3

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Translocation

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Methylation (1kb upstream TSS) (9 2014218-2015218)

Methylation (1kb upstream TSS) (9 2156679-2157679)

Methylation (1kb upstream TSS) (9 2157455-2158455)

CpG Methylation

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  • Official symbol: SMARCA2
  • Full name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
  • Location:
  • Also known as: SNF2LA, SWI2, BAF190, SNF2, hSNF2a, hBRM, SNF2L2, BRM, Sth1p
  • Entrez ID: 6595
  • Ensembl ID: ENSG00000080503

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