SMC1A

structural maintenance of chromosomes 1A

Dependent Cell Lines

CRISPR: 581/582 COMMON ESSENTIAL

RNAi: 318/710

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Common Essential: A gene which, in a large, pan-cancer screen, ranks in the top X most depleting genes in at least 90% of cell lines. X is chosen empirically using the minimum of the distribution of gene ranks in their 90th percentile least depleting lines.


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. AML (1.3e-12)
2. Haematopoietic And Lymphoid (1.1e-11)
3. Leukemia (1.9e-11)
4. Solid (1.9e-11)
5. HER2Amp (2.5e-04)

RNAi

Dependency Score (DEMETER2)

1. Esophagus Squamous (4.6e-07)
2. Esophagus (1.4e-06)
3. Upper Aerodigestive (2.7e-05)
4. Upper Aerodigestive Squamous (2.7e-05)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotUBA10.36
PlotEIF2S30.32
PlotRUVBL10.30
PlotCDK70.29
PlotMED140.28

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotSMC30.52
PlotRAD210.47
PlotMED140.38
PlotSTAG20.34
PlotRSL1D10.32

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Fusion 19Q3

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Translocation

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Methylation (1kb upstream TSS) (23 53449677-53450677)

CpG Methylation

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  • Official symbol: SMC1A
  • Full name: structural maintenance of chromosomes 1A
  • Location:
  • Also known as: SMC1L1, Smcb, KIAA0178, DXS423E, SB1.8
  • Entrez ID: 8243
  • Ensembl ID: ENSG00000072501

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