SNRNP200

small nuclear ribonucleoprotein U5 subunit 200

Dependent Cell Lines

CRISPR: 625/625 COMMON ESSENTIAL

RNAi: 695/710 COMMON ESSENTIAL

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Common Essential: A gene which, in a large, pan-cancer screen, ranks in the top X most depleting genes in at least 90% of cell lines. X is chosen empirically using the minimum of the distribution of gene ranks in their 90th percentile least depleting lines.


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Haematopoietic And Lymphoid (6.7e-17)
2. Solid (5.6e-16)
3. Leukemia (1.3e-10)
4. AML (9.7e-08)
5. Lung NSC (1.2e-04)
6. Multiple Myeloma (3.6e-04)

RNAi

Dependency Score (DEMETER2)

1. Haematopoietic And Lymphoid (5.0e-05)
2. Solid (1.2e-04)
3. HER2Amp (1.8e-04)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotPSMD70.57
PlotSF3A10.52
PlotRAN0.52
PlotSMU10.51
PlotPSMB30.51

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotUSP390.36
PlotPRPF60.34
PlotSF3B60.32
PlotSF3B10.31
PlotIK0.30

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Fusion 19Q3

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Methylation (1kb upstream TSS) (2 96971307-96972307)

CpG Methylation

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  • Official symbol: SNRNP200
  • Full name: small nuclear ribonucleoprotein U5 subunit 200
  • Location:
  • Also known as: U5-200KD, ASCC3L1, HELIC2, RP33, BRR2, KIAA0788
  • Entrez ID: 23020
  • Ensembl ID: ENSG00000144028

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