SOX2

SRY-box 2

Dependent Cell Lines

CRISPR: 21/625 STRONGLY SELECTIVE

RNAi: 4/698 STRONGLY SELECTIVE

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Strongly Selective: A gene whose dependency is at least 100 times more likely to have been sampled from a skewed distribution than a normal distribution (i.e. skewed-LRT value > 100).


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Astrocytoma (1.4e-04)
2. Esophagus Squamous (2.7e-04)
3. Esophagus (3.5e-04)

RNAi

Dependency Score (DEMETER2)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotSOX210.27
PlotCDC14B0.25
PlotATF3-0.23
PlotHABP40.23
PlotLIMK2-0.22

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotTMEM176B0.30
PlotTMEM176B0.30
PlotZFYVE260.26
PlotPRRT30.25
PlotLINC019510.25

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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  • Official symbol: SOX2
  • Full name: SRY-box 2
  • Location:
  • Also known as:
  • Entrez ID: 6657
  • Ensembl ID: ENSG00000181449

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