SPDEF

SAM pointed domain containing ETS transcription factor

Dependent Cell Lines

CRISPR: 9/625 STRONGLY SELECTIVE

RNAi: 22/547 STRONGLY SELECTIVE

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Strongly Selective: A gene whose dependency is at least 100 times more likely to have been sampled from a skewed distribution than a normal distribution (i.e. skewed-LRT value > 100).


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. ERpos (1.6e-25)
2. Breast (7.8e-24)
3. HER2Amp (9.9e-15)

RNAi

Dependency Score (DEMETER2)

1. HER2Amp (1.5e-12)
2. Breast (3.5e-09)
3. TPBC (1.5e-04)
4. ERpos (1.6e-04)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotFOXA10.42
PlotTRPS10.42
PlotESR10.36
PlotGATA30.29
PlotAKT10.28

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotFOXA10.51
PlotSLC36A10.33
PlotSUPV3L10.33
PlotTFAP2C0.32
PlotSH3D190.32

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Fusion 19Q3

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Translocation

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  • Official symbol: SPDEF
  • Full name: SAM pointed domain containing ETS transcription factor
  • Location:
  • Also known as: PDEF, bA375E1.3
  • Entrez ID: 25803
  • Ensembl ID: ENSG00000124664

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