SREBF1

sterol regulatory element binding transcription factor 1

Dependent Cell Lines

CRISPR: 229/625 STRONGLY SELECTIVE

RNAi: 10/710 STRONGLY SELECTIVE

Dependency Score

Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.

Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.

Strongly Selective: A gene whose dependency is at least 100 times more likely to have been sampled from a skewed distribution than a normal distribution (i.e. skewed-LRT value > 100).

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Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Neuroblastoma (3.0e-04)
2. Peripheral Nervous System (3.0e-04)

RNAi

Dependency Score (DEMETER2)

1. Pancreas (7.4e-07)
2. Colorectal MSI (5.4e-05)

Enriched lineages have p-values < 0.0005 shown in parentheses.

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Expression & CN

TPM (log2)

Copy Number log2(relative to ploidy + 1)

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Top Co-dependencies

CRISPR (Avana) Public 19Q3

	Gene	Pearson correlation
Plot	SCD	0.64
Plot	SCAP	0.59
Plot	CYB5B	0.52
Plot	MBTPS1	0.50
Plot	TMEM41A	0.46

Combined RNAi (Broad, Novartis, Marcotte)

	Gene	Pearson correlation
Plot	SCD	0.50
Plot	SCAP	0.47
Plot	UTP3	0.31
Plot	UTP3	0.31
Plot	GXYLT1	-0.28

Target Tractability

Mutations

# of Cell lines

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Description

Search external sites for SREBF1

PubMed ( entries)
GeneCards
GTEx
NCBI

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Choose dataset

CRISPR (Avana) Public 19Q3

CRISPR (GeCKO) 19Q1

CRISPR (Sanger)

Combined RNAi (Broad, Novartis, Marcotte)

RNAi (Broad)

RNAi (Novartis)

Expression Public 19Q3

Copy Number (Absolute)

Copy Number Public 19Q3

Mutation Public 19Q3

Fusion 19Q3

Methylation (1kb upstream TSS) (17 17740325-17741325)

Methylation (1kb upstream TSS) (17 17726978-17727978)

CpG Methylation

Expression Public 19Q3

Copy Number (Absolute)

Copy Number Public 19Q3

Mutation Public 19Q3

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Fusion 19Q3

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Methylation (1kb upstream TSS) (17 17740325-17741325)

Methylation (1kb upstream TSS) (17 17726978-17727978)

CpG Methylation

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Official symbol: SREBF1
Full name: sterol regulatory element binding transcription factor 1
Location:
Also known as: bHLHd1, SREBP-1c, SREBP1a, SREBP1
Entrez ID: 6720
Ensembl ID: ENSG00000072310