SREBF1

sterol regulatory element binding transcription factor 1

Dependent Cell Lines

CRISPR: 229/625 STRONGLY SELECTIVE

RNAi: 10/710 STRONGLY SELECTIVE

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Strongly Selective: A gene whose dependency is at least 100 times more likely to have been sampled from a skewed distribution than a normal distribution (i.e. skewed-LRT value > 100).


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Neuroblastoma (3.0e-04)
2. Peripheral Nervous System (3.0e-04)

RNAi

Dependency Score (DEMETER2)

1. Pancreas (7.4e-07)
2. Colorectal MSI (5.4e-05)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotSCD0.64
PlotSCAP0.59
PlotCYB5B0.52
PlotMBTPS10.50
PlotTMEM41A0.46

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotSCD0.50
PlotSCAP0.47
PlotUTP30.31
PlotUTP30.31
PlotGXYLT1-0.28

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Fusion 19Q3

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Methylation (1kb upstream TSS) (17 17740325-17741325)

Methylation (1kb upstream TSS) (17 17726978-17727978)

CpG Methylation

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  • Official symbol: SREBF1
  • Full name: sterol regulatory element binding transcription factor 1
  • Location:
  • Also known as: bHLHd1, SREBP-1c, SREBP1a, SREBP1
  • Entrez ID: 6720
  • Ensembl ID: ENSG00000072310

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