SSBP1

single stranded DNA binding protein 1

Dependent Cell Lines

CRISPR: 351/625 COMMON ESSENTIAL

RNAi: 256/343

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Common Essential: A gene which, in a large, pan-cancer screen, ranks in the top X most depleting genes in at least 90% of cell lines. X is chosen empirically using the minimum of the distribution of gene ranks in their 90th percentile least depleting lines.


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Esophagus (2.6e-05)
2. Upper Aerodigestive (7.4e-05)
3. Upper Aerodigestive Squamous (9.3e-05)

RNAi

Dependency Score (DEMETER2)

1. Melanoma (1.8e-04)
2. Solid (2.7e-04)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotPTCD10.62
PlotTFB2M0.61
PlotLARS20.60
PlotTFB1M0.59
PlotMRPS330.58

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotNDUFS70.47
PlotMRPS90.41
PlotPTCD30.40
PlotMRPL370.39
PlotSLC30A90.38

Target Tractability



Mutations

# of Cell lines



Description

Loading...  

Search external sites for SSBP1

View details


Choose dataset

Mutation Public 19Q3

Loading table...

Fusion 19Q3

Loading table...

Methylation (1kb upstream TSS) (7 141437120-141438120)

Methylation (1kb upstream TSS) (7 141437406-141438406)

CpG Methylation

Select context(s) and press load



  • Official symbol: SSBP1
  • Full name: single stranded DNA binding protein 1
  • Location:
  • Also known as: mtSSB, SSBP
  • Entrez ID: 6742
  • Ensembl ID: ENSG00000106028

Search external sites for SSBP1