STAMBP

STAM binding protein

Dependent Cell Lines

CRISPR: 182/625 STRONGLY SELECTIVE

RNAi: 10/710

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Strongly Selective: A gene whose dependency is at least 100 times more likely to have been sampled from a skewed distribution than a normal distribution (i.e. skewed-LRT value > 100).


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Upper Aerodigestive (1.9e-07)
2. Upper Aerodigestive Squamous (8.3e-07)
3. Kidney (4.2e-04)

RNAi

Dependency Score (DEMETER2)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotUSP80.38
PlotPTPN230.33
PlotVPS360.31
PlotVPS37A0.23
PlotPTCD30.23

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotUSP80.29
PlotSPATA48-0.28
PlotFAM19A5-0.25
PlotRAB11FIP30.23
PlotPOM121L2-0.22

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Fusion 19Q3

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Translocation

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  • Official symbol: STAMBP
  • Full name: STAM binding protein
  • Location:
  • Also known as: AMSH
  • Entrez ID: 10617
  • Ensembl ID: ENSG00000124356

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