STX4

syntaxin 4

Dependent Cell Lines

CRISPR: 159/625 STRONGLY SELECTIVE

RNAi: 7/547

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Strongly Selective: A gene whose dependency is at least 100 times more likely to have been sampled from a skewed distribution than a normal distribution (i.e. skewed-LRT value > 100).


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Melanoma (2.7e-05)
2. Esophagus Squamous (2.8e-04)
3. Multiple Myeloma (2.9e-04)
4. Upper Aerodigestive Squamous (3.9e-04)

RNAi

Dependency Score (DEMETER2)

1. Multiple Myeloma (1.6e-04)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotSTXBP30.79
PlotSNAP230.50
PlotGRHL20.42
PlotCHMP4B-0.38
PlotRAB100.35

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotUTP3-0.33
PlotUTP3-0.33
PlotCTDSPL20.30
PlotKRTAP1-30.29
PlotSIPA1L30.29

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Fusion 19Q3

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Methylation (1kb upstream TSS) (16 31043811-31044811)

CpG Methylation

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  • Official symbol: STX4
  • Full name: syntaxin 4
  • Location:
  • Also known as: STX4A, p35-2
  • Entrez ID: 6810
  • Ensembl ID: ENSG00000103496

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