TIMM17A

translocase of inner mitochondrial membrane 17A

Dependent Cell Lines

CRISPR: 138/625 STRONGLY SELECTIVE

RNAi: 1/343

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Strongly Selective: A gene whose dependency is at least 100 times more likely to have been sampled from a skewed distribution than a normal distribution (i.e. skewed-LRT value > 100).


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Esophagus Squamous (3.3e-09)
2. Esophagus (7.1e-07)
3. Upper Aerodigestive Squamous (1.6e-06)
4. Upper Aerodigestive (2.5e-06)

RNAi

Dependency Score (DEMETER2)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotPITRM10.33
PlotHSD17B100.33
PlotAIFM10.29
PlotTFB1M0.28
PlotTIMM130.28

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotPIDD10.35
PlotLCT-0.31
PlotWDFY30.31
PlotTCL6-0.30
PlotTCL6-0.30

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Fusion 19Q3

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Methylation (1kb upstream TSS) (1 201923618-201924618)

CpG Methylation

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  • Official symbol: TIMM17A
  • Full name: translocase of inner mitochondrial membrane 17A
  • Location:
  • Also known as: TIM17, TIM17A
  • Entrez ID: 10440
  • Ensembl ID: ENSG00000134375

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