TINAGL1

tubulointerstitial nephritis antigen like 1

Dependent Cell Lines

CRISPR: 1/625

RNAi: 2/547

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.


Enriched Lineages

CRISPR

Dependency Score (CERES)

RNAi

Dependency Score (DEMETER2)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotEPHA80.25
PlotCNR20.23
PlotZNF2540.22
PlotEPHB20.21
PlotPREPL0.21

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotMYO60.40
PlotRNF1510.38
PlotRETN0.37
PlotSPIRE10.37
PlotZNF8800.36

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Fusion 19Q3

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Translocation

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Methylation (1kb upstream TSS) (1 32041085-32042085)

CpG Methylation

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  • Official symbol: TINAGL1
  • Full name: tubulointerstitial nephritis antigen like 1
  • Location:
  • Also known as: ARG1, LIECG3, LCN7, TINAGRP, P3ECSL
  • Entrez ID: 64129
  • Ensembl ID: ENSG00000142910

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