TIPARP

TCDD inducible poly(ADP-ribose) polymerase

Dependent Cell Lines

CRISPR: 131/625

RNAi: 15/710

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Melanoma (5.6e-05)
2. Skin (3.2e-04)

RNAi

Dependency Score (DEMETER2)

1. Melanoma (1.3e-05)
2. Skin (1.5e-05)
3. B-cell ALL (1.7e-04)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotAHR-0.38
PlotARNT-0.36
PlotOGFR-0.27
PlotMETTL150.26
PlotFOSL10.25

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotUTP3-0.37
PlotUTP3-0.37
PlotCFAP440.33
PlotFTO0.33
PlotLYPD10.31

Target Tractability



Mutations

# of Cell lines



Description

Loading...  

Search external sites for TIPARP

View details


Choose dataset

Mutation Public 19Q3

Loading table...

Fusion 19Q3

Loading table...

Translocation

Loading table...

Methylation (1kb upstream TSS) (3 156393452-156394452)

Methylation (1kb upstream TSS) (3 156391714-156392714)

Methylation (1kb upstream TSS) (3 156391204-156392204)

CpG Methylation

Select context(s) and press load



  • Official symbol: TIPARP
  • Full name: TCDD inducible poly(ADP-ribose) polymerase
  • Location:
  • Also known as: DKFZp686N0351, pART14, PARP-7, PARP7, PARP-1, DKFZP434J214, RM1, DDF1
  • Entrez ID: 25976
  • Ensembl ID: ENSG00000163659

Search external sites for TIPARP