TSC2

TSC complex subunit 2

Dependent Cell Lines

CRISPR: 119/625

RNAi: 3/712

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Haematopoietic And Lymphoid (2.9e-11)
2. Solid (3.6e-11)
3. Leukemia (2.6e-07)
4. Central Nervous System (3.0e-05)
5. AML (9.8e-05)
6. Glioma (1.4e-04)

RNAi

Dependency Score (DEMETER2)

1. Haematopoietic And Lymphoid (1.3e-05)
2. Mesothelioma (6.2e-05)
3. Solid (4.8e-04)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotTSC10.93
PlotDEPDC50.53
PlotNPRL20.49
PlotDDIT40.48
PlotPTEN0.37

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotTSC10.38
PlotRPTOR-0.38
PlotKEAP10.35
PlotPPP4C0.34
PlotMTOR-0.34

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Fusion 19Q3

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Translocation

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Methylation (1kb upstream TSS) (16 2096985-2097985)

Methylation (1kb upstream TSS) (16 2096895-2097895)

Methylation (1kb upstream TSS) (16 2097202-2098202)

CpG Methylation

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Protein Array (Tuberin_pT1462)




  • Official symbol: TSC2
  • Full name: TSC complex subunit 2
  • Location:
  • Also known as: LAM, PPP1R160, tuberin, TSC4
  • Entrez ID: 7249
  • Ensembl ID: ENSG00000103197

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