TUBB

tubulin beta class I

Dependent Cell Lines

CRISPR: 622/625 COMMON ESSENTIAL

RNAi: 539/710 COMMON ESSENTIAL

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Common Essential: A gene which, in a large, pan-cancer screen, ranks in the top X most depleting genes in at least 90% of cell lines. X is chosen empirically using the minimum of the distribution of gene ranks in their 90th percentile least depleting lines.


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Solid (8.0e-07)
2. Haematopoietic And Lymphoid (9.9e-07)
3. Colorectal (8.6e-06)
4. Leukemia (1.4e-04)

RNAi

Dependency Score (DEMETER2)

1. Colorectal (4.3e-07)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotTUBA1B0.28
PlotARL20.28
PlotPFDN10.27
PlotSNAPC50.27
PlotEEF1A10.26

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotVEGFD0.46
PlotIL17D0.34
PlotIL17D0.34
PlotNAA380.34
PlotOR1J40.33

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Fusion 19Q3

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Methylation (1kb upstream TSS) (6 30688325-30689325)

Methylation (1kb upstream TSS) (6 30686977-30687977)

CpG Methylation

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  • Official symbol: TUBB
  • Full name: tubulin beta class I
  • Location:
  • Also known as: OK/SW-cl.56, MGC16435, Tubb5, M40
  • Entrez ID: 203068
  • Ensembl ID: ENSG00000196230

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