TUBB4B

tubulin beta 4B class IVb

Dependent Cell Lines

CRISPR: 118/625 STRONGLY SELECTIVE

RNAi: 7/547

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Strongly Selective: A gene whose dependency is at least 100 times more likely to have been sampled from a skewed distribution than a normal distribution (i.e. skewed-LRT value > 100).


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Upper Aerodigestive Squamous (7.1e-07)
2. Upper Aerodigestive (1.4e-06)
3. Colorectal (9.2e-05)

RNAi

Dependency Score (DEMETER2)

1. Upper Aerodigestive (4.5e-04)
2. Upper Aerodigestive Squamous (4.5e-04)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotHMMR0.35
PlotLCN60.34
PlotKLF50.29
PlotLCN80.29
PlotPFDN10.28

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotLETMD10.31
PlotSTOML20.31
PlotCLASP10.30
PlotPLIN5-0.29
PlotCCDC113-0.29

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Fusion 19Q3

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Methylation (1kb upstream TSS) (9 140134710-140135710)

CpG Methylation

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  • Official symbol: TUBB4B
  • Full name: tubulin beta 4B class IVb
  • Location:
  • Also known as: TUBB2C, Beta2
  • Entrez ID: 10383
  • Ensembl ID: ENSG00000188229

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