TUBG1

tubulin gamma 1

Dependent Cell Lines

CRISPR: 620/625 COMMON ESSENTIAL

RNAi: 87/547

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Common Essential: A gene which, in a large, pan-cancer screen, ranks in the top X most depleting genes in at least 90% of cell lines. X is chosen empirically using the minimum of the distribution of gene ranks in their 90th percentile least depleting lines.


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Melanoma (1.3e-10)
2. Skin (3.1e-09)

RNAi

Dependency Score (DEMETER2)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotYARS0.26
PlotCCT30.25
PlotPRC10.25
PlotSOX10-0.25
PlotARL20.25

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotHAUS60.40
PlotPOPDC3-0.34
PlotTOPAZ1-0.32
PlotRPS13-0.31
PlotPATE4-0.31

Target Tractability



Mutations

# of Cell lines



Description

Loading...  

Search external sites for TUBG1

View details


Choose dataset

Mutation Public 19Q3

Loading table...

Fusion 19Q3

Loading table...

Methylation (1kb upstream TSS) (17 40760357-40761357)

CpG Methylation

Select context(s) and press load



  • Official symbol: TUBG1
  • Full name: tubulin gamma 1
  • Location:
  • Also known as: TUBG, TUBGCP1
  • Entrez ID: 7283
  • Ensembl ID: ENSG00000131462

Search external sites for TUBG1