UBE2Z

ubiquitin conjugating enzyme E2 Z

Dependent Cell Lines

CRISPR: 188/625 COMMON ESSENTIAL

RNAi: 5/711

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Common Essential: A gene which, in a large, pan-cancer screen, ranks in the top X most depleting genes in at least 90% of cell lines. X is chosen empirically using the minimum of the distribution of gene ranks in their 90th percentile least depleting lines.


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Colorectal (6.1e-08)
2. Haematopoietic And Lymphoid (1.2e-04)
3. Solid (2.1e-04)
4. Colorectal MSI (4.6e-04)

RNAi

Dependency Score (DEMETER2)

1. Neuroblastoma (3.3e-04)
2. Peripheral Nervous System (3.3e-04)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotCTNNB10.36
PlotTCF7L20.33
PlotGATA60.21
PlotFAM47A0.21
PlotJUP0.21

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotSMIM200.50
PlotMYO60.50
PlotCCDC1540.50
PlotFAM178B0.49
PlotOR56B40.49

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Fusion 19Q3

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  • Official symbol: UBE2Z
  • Full name: ubiquitin conjugating enzyme E2 Z
  • Location:
  • Also known as: USE1, FLJ13855
  • Entrez ID: 65264
  • Ensembl ID: ENSG00000159202

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