UHMK1
U2AF homology motif kinase 1
Dependent Cell Lines
CRISPR: 1/689
RNAi: 0/710
Dependency Score
Enriched Lineages
CRISPR
Dependency Score (CERES)
1. Multiple Myeloma (4.4e-06) n=20
2. Plasma Cell (4.4e-06) n=20
RNAi
Dependency Score (DEMETER2)
1. Melanoma (2.1e-05) n=43
2. Skin (2.1e-04) n=46
Expression & CN
Expression
Copy Number log2(relative to ploidy + 1)
Expression: RNASeq files are aligned with STAR and quantified with RSEM, then TPM-normalized. Reported values are log2(TPM+1).
Copy number: The relative copy number pipeline used varies by cell line. For around 1000 lines, Sanger WES data was used, while for around 700 lines, Broad WES data was used. The remaining lines use SNP array data as explained in 10.1038/s41586-019-1186-3. See 10.1101/720243 for details on how CN source is chosen per line. Lines with WES data were processed through GATK using PONs from TCGA without matched normals and transformed by log2(x+1).
Target Tractability
Description
Choose dataset
Expression Public 19Q4
Copy Number (Absolute)
Copy Number Public 19Q4
Mutation Public 19Q4
Translocation
Methylation (1kb upstream TSS) (1 162466594-162467594)
CpG Methylation
- Official symbol: UHMK1
- Full name: U2AF homology motif kinase 1
- Location:
- Also known as: Kist, KIS
- Entrez ID: 127933
- Ensembl ID: ENSG00000152332
Search external sites for UHMK1
- PubMed ( entries)
- HUGO
- GeneCards
- Wikipedia
- Firebrowse
- Tumor Portal
- GTEx
- COSMIC
- NCBI