VPS4B

vacuolar protein sorting 4 homolog B

Dependent Cell Lines

CRISPR: 75/625 STRONGLY SELECTIVE

RNAi: 100/710 STRONGLY SELECTIVE

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Strongly Selective: A gene whose dependency is at least 100 times more likely to have been sampled from a skewed distribution than a normal distribution (i.e. skewed-LRT value > 100).


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Pancreas (6.3e-05)

RNAi

Dependency Score (DEMETER2)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotIST10.33
PlotVTA10.30
PlotITGA30.28
PlotEFR3A0.27
PlotRAB6A0.26

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotVPS4A0.37
PlotEDEM10.31
PlotTP53I110.28
PlotCHMP2A0.26
PlotMYH10.26

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Fusion 19Q3

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Methylation (1kb upstream TSS) (18 61089752-61090752)

CpG Methylation

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  • Official symbol: VPS4B
  • Full name: vacuolar protein sorting 4 homolog B
  • Location:
  • Also known as: SKD1B, SKD1, VPS4-2
  • Entrez ID: 9525
  • Ensembl ID: ENSG00000119541

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