WDR48

WD repeat domain 48

Dependent Cell Lines

CRISPR: 315/625

RNAi: 17/600

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Central Nervous System (2.8e-07)
2. Glioma (5.2e-07)
3. Glioblastoma (5.2e-05)

RNAi

Dependency Score (DEMETER2)

1. Rhabdoid (7.7e-06)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotUSP10.58
PlotWDR200.27
PlotE2F7-0.27
PlotMDM20.22
PlotTP53-0.22

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotPBOV10.27
PlotUSP10.27
PlotUCN20.25
PlotVPS35L-0.25
PlotMDM40.24

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Fusion 19Q3

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Methylation (1kb upstream TSS) (3 39092476-39093476)

Methylation (1kb upstream TSS) (3 39092782-39093782)

CpG Methylation

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  • Official symbol: WDR48
  • Full name: WD repeat domain 48
  • Location:
  • Also known as: SPG60, P80, KIAA1449
  • Entrez ID: 57599
  • Ensembl ID: ENSG00000114742

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