WDR70

WD repeat domain 70

Dependent Cell Lines

CRISPR: 610/625 COMMON ESSENTIAL

RNAi: 422/554

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Common Essential: A gene which, in a large, pan-cancer screen, ranks in the top X most depleting genes in at least 90% of cell lines. X is chosen empirically using the minimum of the distribution of gene ranks in their 90th percentile least depleting lines.


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Upper Aerodigestive Squamous (2.6e-04)
2. Upper Aerodigestive (2.8e-04)

RNAi

Dependency Score (DEMETER2)

1. Colorectal MSI (4.8e-06)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotNUTF20.38
PlotHNRNPK0.37
PlotTARS0.36
PlotPRIM10.35
PlotANAPC40.34

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotPPWD10.46
PlotBRIX10.42
PlotBRIX10.42
PlotDHX380.42
PlotNKAP0.38

Target Tractability



Mutations

# of Cell lines



Description

Loading...  

Search external sites for WDR70

View details


Choose dataset

Mutation Public 19Q3

Loading table...

Fusion 19Q3

Loading table...

Translocation

Loading table...

Methylation (1kb upstream TSS) (5 37378361-37379361)

CpG Methylation

Select context(s) and press load



  • Official symbol: WDR70
  • Full name: WD repeat domain 70
  • Location:
  • Also known as: FLJ10233
  • Entrez ID: 55100
  • Ensembl ID: ENSG00000082068

Search external sites for WDR70