YRDC

yrdC N6-threonylcarbamoyltransferase domain containing

Dependent Cell Lines

CRISPR: 623/625 COMMON ESSENTIAL

RNAi: 11/343

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Common Essential: A gene which, in a large, pan-cancer screen, ranks in the top X most depleting genes in at least 90% of cell lines. X is chosen empirically using the minimum of the distribution of gene ranks in their 90th percentile least depleting lines.


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Central Nervous System (8.3e-16)
2. Glioma (8.3e-15)
3. Glioblastoma (2.3e-07)
4. Haematopoietic And Lymphoid (1.1e-06)
5. Solid (4.5e-06)
6. Melanoma (5.6e-06)
7. Astrocytoma (6.5e-05)
8. Bone (7.8e-05)
9. Leukemia (2.2e-04)

RNAi

Dependency Score (DEMETER2)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotDTYMK0.63
PlotGMPS0.58
PlotMAT2A0.55
PlotTFRC0.55
PlotADSL0.52

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotPLEKHD10.63
PlotRNF1510.62
PlotUBAP1L0.62
PlotPALM30.61
PlotOR5L20.60

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Fusion 19Q3

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Methylation (1kb upstream TSS) (1 38273865-38274865)

CpG Methylation

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  • Official symbol: YRDC
  • Full name: yrdC N6-threonylcarbamoyltransferase domain containing
  • Location:
  • Also known as: IRIP, SUA5, FLJ23476
  • Entrez ID: 79693
  • Ensembl ID: ENSG00000196449

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