ZRSR2

zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2

Dependent Cell Lines

CRISPR: 581/582 COMMON ESSENTIAL

RNAi: 40/708

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Common Essential: A gene which, in a large, pan-cancer screen, ranks in the top X most depleting genes in at least 90% of cell lines. X is chosen empirically using the minimum of the distribution of gene ranks in their 90th percentile least depleting lines.


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. AML (4.1e-04)

RNAi

Dependency Score (DEMETER2)

1. Colorectal MSI (1.5e-05)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotBUB30.33
PlotSNRNP250.29
PlotRNPC30.28
PlotABCG10.27
PlotHSPE10.26

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotTMEM1690.38
PlotSRP19-0.35
PlotICAM40.33
PlotMLC10.30
PlotDNASE1L20.29

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Methylation (1kb upstream TSS) (23 15807573-15808573)

CpG Methylation

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  • Official symbol: ZRSR2
  • Full name: zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2
  • Location:
  • Also known as: URP, ZC3H22, U2AF1L2, U2AF1-RS2
  • Entrez ID: 8233
  • Ensembl ID: ENSG00000169249

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