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ANLN

Description

anillin actin binding protein

Summary

This gene encodes an actin-binding protein that plays a role in cell growth and migration, and in cytokinesis. The encoded protein is thought to regulate actin cytoskeletal dynamics in podocytes, components of the glomerulus. Mutations in this gene are associated with focal segmental glomerulosclerosis 8. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]

Location

7p14.2

External Links
GeneCards , NCBI

Executive summary

  • ANLN was screened in 0 cell lines with 0 shRNAs, and 285 cell lines with 4 shRNAs.
  • The search for "Related features" MDPs resulted in the most predictive model for ANLN which had an out-of-bag R^2 of 0.26 (FDR 1.94e-02). In addition, this gene had a significant model when searching for the following MDPs: "Unbiased", "Related features".

Dependency profile

Histogram Table
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Scatterplots of dependency vs Expression/Copy Number

Scatterplot Dependency vs Expression

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Scatterplot Dependency vs Copy Number

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Gene's correlated to ANLN's dependency profile

Table genes' correlated

Correlated gene dependency Correlation (r) Z_score

Correlation graph for ANLN

Biomarkers for dependency on ANLN (ATLANTIS)

Context Dependency dataset Biomarker types Biomarker subset Score transform Top biomarker R^2 P-Value FDR Reports

ShRNA Hairpin level scores

55k shRNA library (v2.4.6)

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98k shRNA library (v2.19.2)

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ShRNA Quality

Plot Table
shRNA ID Gene Symbol Seed1 Sequence Seed2 Sequence Gene Rsquared Seed1 Rsquared Seed2 Rsquared Seeds Rsquared Other Gene Rsquared Total Rsquared Alpha1 Alpha2 Beta Other Gene Symbol

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