DepMap - Broad Institute

ADP ribosylation factor like GTPase 15

None

5q11.2

GeneCards , NCBI

Executive summary

ARL15 was screened in 216 cell lines with 5 shRNAs, and 285 cell lines with 5 shRNAs.
The search for "Mutation driven" MDPs resulted in the most predictive model for ARL15 which had an out-of-bag R^2 of 0.22 (FDR 3.10e-02). In addition, this gene had a significant model when searching for the following MDPs: "Mutation driven".

Dependency profile

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Scatterplots of dependency vs Expression/Copy Number

Scatterplot Dependency vs Expression

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Scatterplot Dependency vs Copy Number

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Gene's correlated to ARL15's dependency profile

Table genes' correlated

Correlated gene dependency	Correlation (r)	Z_score

Correlation graph for ARL15

Biomarkers for dependency on ARL15 (ATLANTIS)

Context	Dependency dataset	Biomarker types	Biomarker subset	Score transform	Top biomarker	R^2	P-Value	FDR	Reports

ShRNA Hairpin level scores

55k shRNA library (v2.4.6)

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98k shRNA library (v2.19.2)

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ShRNA Quality

shRNA ID	Gene Symbol	Seed1 Sequence	Seed2 Sequence	Gene Rsquared	Seed1 Rsquared	Seed2 Rsquared	Seeds Rsquared	Other Gene Rsquared	Total Rsquared	Alpha1	Alpha2	Beta	Other Gene Symbol