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BIRC6

Description

baculoviral IAP repeat containing 6

Summary

This gene encodes a protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. This protein inhibits apoptosis by facilitating the degradation of apoptotic proteins by ubiquitination. [provided by RefSeq, Jul 2008]

Location

2p22.3

External Links
GeneCards , NCBI

Executive summary

  • BIRC6 was screened in 216 cell lines with 5 shRNAs, and 285 cell lines with 10 shRNAs.
  • The search for "Unbiased" MDPs resulted in the most predictive model for BIRC6 which had an out-of-bag R^2 of 0.25 (FDR 3.93e-02). In addition, this gene had a significant model when searching for the following MDPs: "Unbiased", "Related features".
  • BIRC6 was annotated as potentially druggable (either in DGIDB or IUPHAR/BPS Guide to PHARMACOLOGY).

Dependency profile

Histogram Table
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Scatterplots of dependency vs Expression/Copy Number

Scatterplot Dependency vs Expression

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Scatterplot Dependency vs Copy Number

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Gene's correlated to BIRC6's dependency profile

Table genes' correlated

Correlated gene dependency Correlation (r) Z_score

Correlation graph for BIRC6

Biomarkers for dependency on BIRC6 (ATLANTIS)

Context Dependency dataset Biomarker types Biomarker subset Score transform Top biomarker R^2 P-Value FDR Reports

ShRNA Hairpin level scores

55k shRNA library (v2.4.6)

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98k shRNA library (v2.19.2)

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ShRNA Quality

Plot Table
shRNA ID Gene Symbol Seed1 Sequence Seed2 Sequence Gene Rsquared Seed1 Rsquared Seed2 Rsquared Seeds Rsquared Other Gene Rsquared Total Rsquared Alpha1 Alpha2 Beta Other Gene Symbol

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