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CBLL1

Description

Cbl proto-oncogene like 1

Summary

This gene encodes an E3 ubiquitin-ligase for the E-cadherin complex and mediates its ubiquitination, endocytosis, and degradation in the lysosomes. The encoded protein contains a RING-finger domain and is also thought to have a role in control of cell proliferation. A related pseudogene has been identified on chromosome X. Alternative splicing results in a non-coding transcript variant. [provided by RefSeq, Aug 2011]

Location

7q22.3

External Links
GeneCards , NCBI

Executive summary

  • CBLL1 was screened in 216 cell lines with 5 shRNAs, and 285 cell lines with 5 shRNAs.
  • CBLL1 was a six-sigma dependency in 2 cell lines.
  • No significant models found for CBLL1

Dependency profile

Histogram Table
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Scatterplots of dependency vs Expression/Copy Number

Scatterplot Dependency vs Expression

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Scatterplot Dependency vs Copy Number

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Gene's correlated to CBLL1's dependency profile

Table genes' correlated

Correlated gene dependency Correlation (r) Z_score

Correlation graph for CBLL1

Biomarkers for dependency on CBLL1 (ATLANTIS)

Context Dependency dataset Biomarker types Biomarker subset Score transform Top biomarker R^2 P-Value FDR Reports

ShRNA Hairpin level scores

55k shRNA library (v2.4.6)

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98k shRNA library (v2.19.2)

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ShRNA Quality

Plot Table
shRNA ID Gene Symbol Seed1 Sequence Seed2 Sequence Gene Rsquared Seed1 Rsquared Seed2 Rsquared Seeds Rsquared Other Gene Rsquared Total Rsquared Alpha1 Alpha2 Beta Other Gene Symbol

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