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CCNK

Description

cyclin K

Summary

The protein encoded by this gene is a member of the transcription cyclin family. These cyclins may regulate transcription through their association with and activation of cyclin-dependent kinases (CDK) that phosphorylate the C-terminal domain (CTD) of the large subunit of RNA polymerase II. This gene product may play a dual role in regulating CDK and RNA polymerase II activities. [provided by RefSeq, Jul 2008]

Location

14q32.2

External Links
GeneCards , NCBI

Executive summary

  • CCNK was screened in 216 cell lines with 5 shRNAs, and 285 cell lines with 5 shRNAs.
  • CCNK was a six-sigma dependency in 12 cell lines.
  • The search for "CYCLOPS" MDPs resulted in the most predictive model for CCNK which had an out-of-bag R^2 of 0.11 (FDR 3.79e-02). In addition, this gene had a significant model when searching for the following MDPs: "CYCLOPS".

Dependency profile

Histogram Table
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Scatterplots of dependency vs Expression/Copy Number

Scatterplot Dependency vs Expression

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Scatterplot Dependency vs Copy Number

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Gene's correlated to CCNK's dependency profile

Table genes' correlated

Correlated gene dependency Correlation (r) Z_score

Correlation graph for CCNK

Biomarkers for dependency on CCNK (ATLANTIS)

Context Dependency dataset Biomarker types Biomarker subset Score transform Top biomarker R^2 P-Value FDR Reports

ShRNA Hairpin level scores

55k shRNA library (v2.4.6)

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98k shRNA library (v2.19.2)

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ShRNA Quality

Plot Table
shRNA ID Gene Symbol Seed1 Sequence Seed2 Sequence Gene Rsquared Seed1 Rsquared Seed2 Rsquared Seeds Rsquared Other Gene Rsquared Total Rsquared Alpha1 Alpha2 Beta Other Gene Symbol

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