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CDK11B

Description

cyclin dependent kinase 11B

Summary

This gene encodes a member of the serine/threonine protein kinase family. Members of this kinase family are known to be essential for eukaryotic cell cycle control. Due to a segmental duplication, this gene shares very high sequence identity with a neighboring gene. These two genes are frequently deleted or altered in neuroblastoma. The protein kinase encoded by this gene can be cleaved by caspases and may play a role in cell apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

Location

1p36.33

External Links
GeneCards , NCBI

Executive summary

  • CDK11B was screened in 216 cell lines with 5 shRNAs, and 285 cell lines with 12 shRNAs.
  • The search for "Related features" MDPs resulted in the most predictive model for CDK11B which had an out-of-bag R^2 of 0.21 (FDR 2.84e-02). In addition, this gene had a significant model when searching for the following MDPs: "Related features".
  • CDK11B was annotated as potentially druggable (either in DGIDB or IUPHAR/BPS Guide to PHARMACOLOGY).

Dependency profile

Histogram Table
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Scatterplots of dependency vs Expression/Copy Number

Scatterplot Dependency vs Expression

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Scatterplot Dependency vs Copy Number

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Gene's correlated to CDK11B's dependency profile

Table genes' correlated

Correlated gene dependency Correlation (r) Z_score

Correlation graph for CDK11B

Biomarkers for dependency on CDK11B (ATLANTIS)

Context Dependency dataset Biomarker types Biomarker subset Score transform Top biomarker R^2 P-Value FDR Reports

ShRNA Hairpin level scores

55k shRNA library (v2.4.6)

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98k shRNA library (v2.19.2)

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ShRNA Quality

Plot Table
shRNA ID Gene Symbol Seed1 Sequence Seed2 Sequence Gene Rsquared Seed1 Rsquared Seed2 Rsquared Seeds Rsquared Other Gene Rsquared Total Rsquared Alpha1 Alpha2 Beta Other Gene Symbol

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