Home
Contact us
Home

CTNNBL1

Description

catenin beta like 1

Summary

The protein encoded by this gene is a component of the pre-mRNA-processing factor 19-cell division cycle 5-like (PRP19-CDC5L) protein complex, which activates pre-mRNA splicing and is an integral part of the spliceosome. The encoded protein is also a nuclear localization sequence binding protein, and binds to activation-induced deaminase and is important for antibody diversification. This gene may also be associated with the development of obesity. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been defined on the X chromosome. [provided by RefSeq, Jul 2013]

Location

20q11.23

External Links
GeneCards , NCBI

Executive summary

  • CTNNBL1 was screened in 216 cell lines with 5 shRNAs, and 285 cell lines with 5 shRNAs.
  • CTNNBL1 was a six-sigma dependency in 10 cell lines.
  • The search for "Unbiased" MDPs resulted in the most predictive model for CTNNBL1 which had an out-of-bag R^2 of 0.25 (FDR 4.02e-02). In addition, this gene had a significant model when searching for the following MDPs: "Unbiased", "Related features", "CYCLOPS".

Dependency profile

Histogram Table
Loading graph
Download

Scatterplots of dependency vs Expression/Copy Number

Scatterplot Dependency vs Expression

Placeholder while we fetch the data
Loading graph

Scatterplot Dependency vs Copy Number

Placeholder while we fetch the data
Loading graph

Gene's correlated to CTNNBL1's dependency profile

Table genes' correlated

Correlated gene dependency Correlation (r) Z_score

Correlation graph for CTNNBL1

Biomarkers for dependency on CTNNBL1 (ATLANTIS)

Context Dependency dataset Biomarker types Biomarker subset Score transform Top biomarker R^2 P-Value FDR Reports

ShRNA Hairpin level scores

55k shRNA library (v2.4.6)

Loading graph

98k shRNA library (v2.19.2)

Loading graph

ShRNA Quality

Plot Table
shRNA ID Gene Symbol Seed1 Sequence Seed2 Sequence Gene Rsquared Seed1 Rsquared Seed2 Rsquared Seeds Rsquared Other Gene Rsquared Total Rsquared Alpha1 Alpha2 Beta Other Gene Symbol

About

Contact Us

Website built by Cancer Data Science - Broad Institute of MIT and Harvard