Home
Contact us
Home

DHDDS

Description

dehydrodolichyl diphosphate synthase subunit

Summary

The protein encoded by this gene catalyzes cis-prenyl chain elongation to produce the polyprenyl backbone of dolichol, a glycosyl carrier lipid required for the biosynthesis of several classes of glycoproteins. Mutations in this gene are associated with retinitis pigmentosa type 59. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

Location

1p36.11

External Links
GeneCards , NCBI

Executive summary

  • DHDDS was screened in 216 cell lines with 4 shRNAs, and 285 cell lines with 4 shRNAs.
  • DHDDS was a six-sigma dependency in 8 cell lines.
  • The search for "Related features" MDPs resulted in the most predictive model for DHDDS which had an out-of-bag R^2 of 0.22 (FDR 2.36e-02). In addition, this gene had a significant model when searching for the following MDPs: "Related features", "CYCLOPS".

Dependency profile

Histogram Table
Loading graph
Download

Scatterplots of dependency vs Expression/Copy Number

Scatterplot Dependency vs Expression

Placeholder while we fetch the data
Loading graph

Scatterplot Dependency vs Copy Number

Placeholder while we fetch the data
Loading graph

Gene's correlated to DHDDS's dependency profile

Table genes' correlated

Correlated gene dependency Correlation (r) Z_score

Correlation graph for DHDDS

Biomarkers for dependency on DHDDS (ATLANTIS)

Context Dependency dataset Biomarker types Biomarker subset Score transform Top biomarker R^2 P-Value FDR Reports

ShRNA Hairpin level scores

55k shRNA library (v2.4.6)

Loading graph

98k shRNA library (v2.19.2)

Loading graph

ShRNA Quality

Plot Table
shRNA ID Gene Symbol Seed1 Sequence Seed2 Sequence Gene Rsquared Seed1 Rsquared Seed2 Rsquared Seeds Rsquared Other Gene Rsquared Total Rsquared Alpha1 Alpha2 Beta Other Gene Symbol

About

Contact Us

Website built by Cancer Data Science - Broad Institute of MIT and Harvard