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EEF2

Description

eukaryotic translation elongation factor 2

Summary

This gene encodes a member of the GTP-binding translation elongation factor family. This protein is an essential factor for protein synthesis. It promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome. This protein is completely inactivated by EF-2 kinase phosporylation. [provided by RefSeq, Jul 2008]

Location

19p13.3

External Links
GeneCards , NCBI

Executive summary

  • EEF2 was screened in 216 cell lines with 5 shRNAs, and 285 cell lines with 5 shRNAs.
  • EEF2 was a six-sigma dependency in 8 cell lines.
  • The search for "Related features" MDPs resulted in the most predictive model for EEF2 which had an out-of-bag R^2 of 0.33 (FDR 1.03e-02). In addition, this gene had a significant model when searching for the following MDPs: "Unbiased", "Related features", "CYCLOPS".
  • EEF2 was annotated as potentially druggable (either in DGIDB or IUPHAR/BPS Guide to PHARMACOLOGY).

Dependency profile

Histogram Table
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Scatterplots of dependency vs Expression/Copy Number

Scatterplot Dependency vs Expression

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Scatterplot Dependency vs Copy Number

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Gene's correlated to EEF2's dependency profile

Table genes' correlated

Correlated gene dependency Correlation (r) Z_score

Correlation graph for EEF2

Biomarkers for dependency on EEF2 (ATLANTIS)

Context Dependency dataset Biomarker types Biomarker subset Score transform Top biomarker R^2 P-Value FDR Reports

ShRNA Hairpin level scores

55k shRNA library (v2.4.6)

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98k shRNA library (v2.19.2)

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ShRNA Quality

Plot Table
shRNA ID Gene Symbol Seed1 Sequence Seed2 Sequence Gene Rsquared Seed1 Rsquared Seed2 Rsquared Seeds Rsquared Other Gene Rsquared Total Rsquared Alpha1 Alpha2 Beta Other Gene Symbol

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