Home
Contact us
Home

EIF2B2

Description

eukaryotic translation initiation factor 2B subunit beta

Summary

This gene encodes the beta subunit of eukaryotic initiation factor-2B (EIF2B). EIF2B is involved in protein synthesis and exchanges GDP and GTP for its activation and deactivation. [provided by RefSeq, Aug 2011]

Location

14q24.3

External Links
GeneCards , NCBI

Executive summary

  • EIF2B2 was screened in 216 cell lines with 4 shRNAs, and 285 cell lines with 4 shRNAs.
  • The search for "Related features" MDPs resulted in the most predictive model for EIF2B2 which had an out-of-bag R^2 of 0.19 (FDR 3.22e-02). In addition, this gene had a significant model when searching for the following MDPs: "Related features", "CYCLOPS".

Dependency profile

Histogram Table
Loading graph
Download

Scatterplots of dependency vs Expression/Copy Number

Scatterplot Dependency vs Expression

Placeholder while we fetch the data
Loading graph

Scatterplot Dependency vs Copy Number

Placeholder while we fetch the data
Loading graph

Gene's correlated to EIF2B2's dependency profile

Table genes' correlated

Correlated gene dependency Correlation (r) Z_score

Correlation graph for EIF2B2

Biomarkers for dependency on EIF2B2 (ATLANTIS)

Context Dependency dataset Biomarker types Biomarker subset Score transform Top biomarker R^2 P-Value FDR Reports

ShRNA Hairpin level scores

55k shRNA library (v2.4.6)

Loading graph

98k shRNA library (v2.19.2)

Loading graph

ShRNA Quality

Plot Table
shRNA ID Gene Symbol Seed1 Sequence Seed2 Sequence Gene Rsquared Seed1 Rsquared Seed2 Rsquared Seeds Rsquared Other Gene Rsquared Total Rsquared Alpha1 Alpha2 Beta Other Gene Symbol

About

Contact Us

Website built by Cancer Data Science - Broad Institute of MIT and Harvard