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EIF3CL

Description

eukaryotic translation initiation factor 3 subunit C like

Summary

The protein encoded by this gene is a core subunit of the eukaryotic translation initiation factor 3 (eIF3) complex. The encoded protein is nearly identical to another protein, eIF3c, from a related gene. The eIF3 complex binds the 40S ribosome and mRNAs to enable translation initiation. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2015]

Location

16p12.1

External Links
GeneCards , NCBI

Executive summary

  • EIF3CL was screened in 0 cell lines with 0 shRNAs, and 285 cell lines with 5 shRNAs.
  • The search for "Related features" MDPs resulted in the most predictive model for EIF3CL which had an out-of-bag R^2 of 0.28 (FDR 1.94e-02). In addition, this gene had a significant model when searching for the following MDPs: "Unbiased", "Related features", "CYCLOPS", "Paralog".

Dependency profile

Histogram Table
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Scatterplots of dependency vs Expression/Copy Number

Scatterplot Dependency vs Expression

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Scatterplot Dependency vs Copy Number

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Gene's correlated to EIF3CL's dependency profile

Table genes' correlated

Correlated gene dependency Correlation (r) Z_score

Correlation graph for EIF3CL

Biomarkers for dependency on EIF3CL (ATLANTIS)

Context Dependency dataset Biomarker types Biomarker subset Score transform Top biomarker R^2 P-Value FDR Reports

ShRNA Hairpin level scores

55k shRNA library (v2.4.6)

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98k shRNA library (v2.19.2)

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ShRNA Quality

Plot Table
shRNA ID Gene Symbol Seed1 Sequence Seed2 Sequence Gene Rsquared Seed1 Rsquared Seed2 Rsquared Seeds Rsquared Other Gene Rsquared Total Rsquared Alpha1 Alpha2 Beta Other Gene Symbol

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