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FASTKD2

Description

FAST kinase domains 2

Summary

This gene encodes a protein that is localized in the mitochondrial inner compartment and that may play a role in mitochondrial apoptosis. Nonsense mutations have been reported to result in cytochrome c oxidase deficiency. [provided by RefSeq, Oct 2008]

Location

2q33.3

External Links
GeneCards , NCBI

Executive summary

  • FASTKD2 was screened in 0 cell lines with 0 shRNAs, and 285 cell lines with 10 shRNAs.
  • The search for "Related features" MDPs resulted in the most predictive model for FASTKD2 which had an out-of-bag R^2 of 0.15 (FDR 4.64e-02). In addition, this gene had a significant model when searching for the following MDPs: "Related features".

Dependency profile

Histogram Table
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Scatterplots of dependency vs Expression/Copy Number

Scatterplot Dependency vs Expression

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Scatterplot Dependency vs Copy Number

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Gene's correlated to FASTKD2's dependency profile

Table genes' correlated

Correlated gene dependency Correlation (r) Z_score

Correlation graph for FASTKD2

Biomarkers for dependency on FASTKD2 (ATLANTIS)

Context Dependency dataset Biomarker types Biomarker subset Score transform Top biomarker R^2 P-Value FDR Reports

ShRNA Hairpin level scores

55k shRNA library (v2.4.6)

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98k shRNA library (v2.19.2)

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ShRNA Quality

Plot Table
shRNA ID Gene Symbol Seed1 Sequence Seed2 Sequence Gene Rsquared Seed1 Rsquared Seed2 Rsquared Seeds Rsquared Other Gene Rsquared Total Rsquared Alpha1 Alpha2 Beta Other Gene Symbol

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