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GNL3

Description

G protein nucleolar 3

Summary

The protein encoded by this gene may interact with p53 and may be involved in tumorigenesis. The encoded protein also appears to be important for stem cell proliferation. This protein is found in both the nucleus and nucleolus. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

Location

3p21.1

External Links
GeneCards , NCBI

Executive summary

  • GNL3 was screened in 216 cell lines with 5 shRNAs, and 285 cell lines with 6 shRNAs.
  • The search for "Unbiased" MDPs resulted in the most predictive model for GNL3 which had an out-of-bag R^2 of 0.23 (FDR 4.39e-02). In addition, this gene had a significant model when searching for the following MDPs: "Unbiased".

Dependency profile

Histogram Table
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Scatterplots of dependency vs Expression/Copy Number

Scatterplot Dependency vs Expression

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Scatterplot Dependency vs Copy Number

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Gene's correlated to GNL3's dependency profile

Table genes' correlated

Correlated gene dependency Correlation (r) Z_score

Correlation graph for GNL3

Biomarkers for dependency on GNL3 (ATLANTIS)

Context Dependency dataset Biomarker types Biomarker subset Score transform Top biomarker R^2 P-Value FDR Reports

ShRNA Hairpin level scores

55k shRNA library (v2.4.6)

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98k shRNA library (v2.19.2)

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ShRNA Quality

Plot Table
shRNA ID Gene Symbol Seed1 Sequence Seed2 Sequence Gene Rsquared Seed1 Rsquared Seed2 Rsquared Seeds Rsquared Other Gene Rsquared Total Rsquared Alpha1 Alpha2 Beta Other Gene Symbol

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