HIST1H2AK

Description

histone cluster 1 H2A family member k

Summary

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]

Location

6p22.1

External Links
GeneCards , NCBI

Executive summary

  • HIST1H2AK was screened in 216 cell lines with 8 shRNAs, and 285 cell lines with 10 shRNAs.
  • The search for "Unbiased" MDPs resulted in the most predictive model for HIST1H2AK which had an out-of-bag R^2 of 0.28 (FDR 3.48e-02). In addition, this gene had a significant model when searching for the following MDPs: "Unbiased", "Related features".

Dependency profile

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Scatterplots of dependency vs Expression/Copy Number

Scatterplot Dependency vs Expression

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Scatterplot Dependency vs Copy Number

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Gene's correlated to HIST1H2AK's dependency profile

Table genes' correlated

Correlated gene dependency Correlation (r) Z_score

Correlation graph for HIST1H2AK

Biomarkers for dependency on HIST1H2AK (ATLANTIS)

Context Dependency dataset Biomarker types Biomarker subset Score transform Top biomarker R^2 P-Value FDR Reports

ShRNA Hairpin level scores

55k shRNA library (v2.4.6)

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98k shRNA library (v2.19.2)

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ShRNA Quality

shRNA ID Gene Symbol Seed1 Sequence Seed2 Sequence Gene Rsquared Seed1 Rsquared Seed2 Rsquared Seeds Rsquared Other Gene Rsquared Total Rsquared Alpha1 Alpha2 Beta Other Gene Symbol