Home
Contact us
Home

ITPK1

Description

inositol-tetrakisphosphate 1-kinase

Summary

This gene encodes an enzyme that belongs to the inositol 1,3,4-trisphosphate 5/6-kinase family. This enzyme regulates the synthesis of inositol tetraphosphate, and downstream products, inositol pentakisphosphate and inositol hexakisphosphate. Inositol metabolism plays a role in the development of the neural tube. Disruptions in this gene are thought to be associated with neural tube defects. A pseudogene of this gene has been identified on chromosome X. [provided by RefSeq, Jul 2016]

Location

14q32.12

External Links
GeneCards , NCBI

Executive summary

  • ITPK1 was screened in 216 cell lines with 4 shRNAs, and 285 cell lines with 5 shRNAs.
  • No significant models found for ITPK1

Dependency profile

Histogram Table
Loading graph
Download

Scatterplots of dependency vs Expression/Copy Number

Scatterplot Dependency vs Expression

Placeholder while we fetch the data
Loading graph

Scatterplot Dependency vs Copy Number

Placeholder while we fetch the data
Loading graph

Gene's correlated to ITPK1's dependency profile

Table genes' correlated

Correlated gene dependency Correlation (r) Z_score

Correlation graph for ITPK1

Biomarkers for dependency on ITPK1 (ATLANTIS)

Context Dependency dataset Biomarker types Biomarker subset Score transform Top biomarker R^2 P-Value FDR Reports

ShRNA Hairpin level scores

55k shRNA library (v2.4.6)

Loading graph

98k shRNA library (v2.19.2)

Loading graph

ShRNA Quality

Plot Table
shRNA ID Gene Symbol Seed1 Sequence Seed2 Sequence Gene Rsquared Seed1 Rsquared Seed2 Rsquared Seeds Rsquared Other Gene Rsquared Total Rsquared Alpha1 Alpha2 Beta Other Gene Symbol

About

Contact Us

Website built by Cancer Data Science - Broad Institute of MIT and Harvard