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jagged 1

The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis. [provided by RefSeq, Jul 2008]

20p12.2

GeneCards , NCBI

Executive summary

JAG1 was screened in 216 cell lines with 5 shRNAs, and 285 cell lines with 5 shRNAs.
No significant models found for JAG1

Dependency profile

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Scatterplots of dependency vs Expression/Copy Number

Scatterplot Dependency vs Expression

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Scatterplot Dependency vs Copy Number

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Gene's correlated to JAG1's dependency profile

Table genes' correlated

Correlated gene dependency	Correlation (r)	Z_score

Correlation graph for JAG1

Biomarkers for dependency on JAG1 (ATLANTIS)

Context	Dependency dataset	Biomarker types	Biomarker subset	Score transform	Top biomarker	R^2	P-Value	FDR	Reports

ShRNA Hairpin level scores

55k shRNA library (v2.4.6)

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98k shRNA library (v2.19.2)

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ShRNA Quality

shRNA ID	Gene Symbol	Seed1 Sequence	Seed2 Sequence	Gene Rsquared	Seed1 Rsquared	Seed2 Rsquared	Seeds Rsquared	Other Gene Rsquared	Total Rsquared	Alpha1	Alpha2	Beta	Other Gene Symbol

JAG1

Executive summary

Dependency profile

Scatterplots of dependency vs Expression/Copy Number

Scatterplot Dependency vs Expression

Scatterplot Dependency vs Copy Number

Gene's correlated to JAG1's dependency profile

Table genes' correlated

Correlation graph for JAG1

Biomarkers for dependency on JAG1 (ATLANTIS)

ShRNA Hairpin level scores

55k shRNA library (v2.4.6)

98k shRNA library (v2.19.2)

ShRNA Quality

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