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KMT2C

Description

lysine methyltransferase 2C

Summary

This gene is a member of the myeloid/lymphoid or mixed-lineage leukemia (MLL) family and encodes a nuclear protein with an AT hook DNA-binding domain, a DHHC-type zinc finger, six PHD-type zinc fingers, a SET domain, a post-SET domain and a RING-type zinc finger. This protein is a member of the ASC-2/NCOA6 complex (ASCOM), which possesses histone methylation activity and is involved in transcriptional coactivation. [provided by RefSeq, Jul 2008]

Location

7q36.1

External Links
GeneCards , NCBI

Executive summary

  • KMT2C was screened in 216 cell lines with 5 shRNAs, and 285 cell lines with 20 shRNAs.
  • The search for "Unbiased" MDPs resulted in the most predictive model for KMT2C which had an out-of-bag R^2 of 0.26 (FDR 3.93e-02). In addition, this gene had a significant model when searching for the following MDPs: "Unbiased", "Related features".
  • KMT2C was annotated as potentially druggable (either in DGIDB or IUPHAR/BPS Guide to PHARMACOLOGY).

Dependency profile

Histogram Table
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Scatterplots of dependency vs Expression/Copy Number

Scatterplot Dependency vs Expression

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Scatterplot Dependency vs Copy Number

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Gene's correlated to KMT2C's dependency profile

Table genes' correlated

Correlated gene dependency Correlation (r) Z_score

Correlation graph for KMT2C

Biomarkers for dependency on KMT2C (ATLANTIS)

Context Dependency dataset Biomarker types Biomarker subset Score transform Top biomarker R^2 P-Value FDR Reports

ShRNA Hairpin level scores

55k shRNA library (v2.4.6)

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98k shRNA library (v2.19.2)

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ShRNA Quality

Plot Table
shRNA ID Gene Symbol Seed1 Sequence Seed2 Sequence Gene Rsquared Seed1 Rsquared Seed2 Rsquared Seeds Rsquared Other Gene Rsquared Total Rsquared Alpha1 Alpha2 Beta Other Gene Symbol

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