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LSM2

Description

LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated

Summary

This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Pseudogenes of this gene are located on the short arm of chromosomes 6 and 19. [provided by RefSeq, Nov 2011]

Location

6p21.33

External Links
GeneCards , NCBI

Executive summary

  • LSM2 was screened in 216 cell lines with 5 shRNAs, and 285 cell lines with 5 shRNAs.
  • LSM2 was a six-sigma dependency in 8 cell lines.
  • The search for "Related features" MDPs resulted in the most predictive model for LSM2 which had an out-of-bag R^2 of 0.24 (FDR 2.08e-02). In addition, this gene had a significant model when searching for the following MDPs: "Related features", "CYCLOPS".

Dependency profile

Histogram Table
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Scatterplots of dependency vs Expression/Copy Number

Scatterplot Dependency vs Expression

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Scatterplot Dependency vs Copy Number

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Gene's correlated to LSM2's dependency profile

Table genes' correlated

Correlated gene dependency Correlation (r) Z_score

Correlation graph for LSM2

Biomarkers for dependency on LSM2 (ATLANTIS)

Context Dependency dataset Biomarker types Biomarker subset Score transform Top biomarker R^2 P-Value FDR Reports

ShRNA Hairpin level scores

55k shRNA library (v2.4.6)

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98k shRNA library (v2.19.2)

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ShRNA Quality

Plot Table
shRNA ID Gene Symbol Seed1 Sequence Seed2 Sequence Gene Rsquared Seed1 Rsquared Seed2 Rsquared Seeds Rsquared Other Gene Rsquared Total Rsquared Alpha1 Alpha2 Beta Other Gene Symbol

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