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LSM6

Description

LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated

Summary

Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Apr 2004]

Location

4q31.22

External Links
GeneCards , NCBI

Executive summary

  • LSM6 was screened in 216 cell lines with 4 shRNAs, and 285 cell lines with 5 shRNAs.
  • The search for "CYCLOPS" MDPs resulted in the most predictive model for LSM6 which had an out-of-bag R^2 of 0.1 (FDR 4.28e-02). In addition, this gene had a significant model when searching for the following MDPs: "CYCLOPS".

Dependency profile

Histogram Table
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Scatterplots of dependency vs Expression/Copy Number

Scatterplot Dependency vs Expression

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Scatterplot Dependency vs Copy Number

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Gene's correlated to LSM6's dependency profile

Table genes' correlated

Correlated gene dependency Correlation (r) Z_score

Correlation graph for LSM6

Biomarkers for dependency on LSM6 (ATLANTIS)

Context Dependency dataset Biomarker types Biomarker subset Score transform Top biomarker R^2 P-Value FDR Reports

ShRNA Hairpin level scores

55k shRNA library (v2.4.6)

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98k shRNA library (v2.19.2)

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ShRNA Quality

Plot Table
shRNA ID Gene Symbol Seed1 Sequence Seed2 Sequence Gene Rsquared Seed1 Rsquared Seed2 Rsquared Seeds Rsquared Other Gene Rsquared Total Rsquared Alpha1 Alpha2 Beta Other Gene Symbol

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