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MAD2L1

Description

mitotic arrest deficient 2 like 1

Summary

MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L1 is related to the MAD2L2 gene located on chromosome 1. A MAD2 pseudogene has been mapped to chromosome 14. [provided by RefSeq, Jul 2008]

Location

4q27

External Links
GeneCards , NCBI

Executive summary

  • MAD2L1 was screened in 216 cell lines with 5 shRNAs, and 285 cell lines with 5 shRNAs.
  • MAD2L1 was a six-sigma dependency in 13 cell lines.
  • The search for "Related features" MDPs resulted in the most predictive model for MAD2L1 which had an out-of-bag R^2 of 0.15 (FDR 4.50e-02). In addition, this gene had a significant model when searching for the following MDPs: "Related features".

Dependency profile

Histogram Table
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Scatterplots of dependency vs Expression/Copy Number

Scatterplot Dependency vs Expression

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Scatterplot Dependency vs Copy Number

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Gene's correlated to MAD2L1's dependency profile

Table genes' correlated

Correlated gene dependency Correlation (r) Z_score

Correlation graph for MAD2L1

Biomarkers for dependency on MAD2L1 (ATLANTIS)

Context Dependency dataset Biomarker types Biomarker subset Score transform Top biomarker R^2 P-Value FDR Reports

ShRNA Hairpin level scores

55k shRNA library (v2.4.6)

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98k shRNA library (v2.19.2)

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ShRNA Quality

Plot Table
shRNA ID Gene Symbol Seed1 Sequence Seed2 Sequence Gene Rsquared Seed1 Rsquared Seed2 Rsquared Seeds Rsquared Other Gene Rsquared Total Rsquared Alpha1 Alpha2 Beta Other Gene Symbol

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