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MAP3K13

Description

mitogen-activated protein kinase kinase kinase 13

Summary

The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a dual leucine-zipper motif, and has been shown to form dimers/oligomers through its leucine-zipper motif. This kinase can phosphorylate and activate MAPK8/JNK, MAP2K7/MKK7, which suggests a role in the JNK signaling pathway. [provided by RefSeq, Jul 2008]

Location

3q27.2

External Links
GeneCards , NCBI

Executive summary

  • MAP3K13 was screened in 216 cell lines with 5 shRNAs, and 285 cell lines with 9 shRNAs.
  • The search for "Unbiased" MDPs resulted in the most predictive model for MAP3K13 which had an out-of-bag R^2 of 0.29 (FDR 3.37e-02). In addition, this gene had a significant model when searching for the following MDPs: "Unbiased", "Related features".
  • MAP3K13 was annotated as potentially druggable (either in DGIDB or IUPHAR/BPS Guide to PHARMACOLOGY).

Dependency profile

Histogram Table
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Scatterplots of dependency vs Expression/Copy Number

Scatterplot Dependency vs Expression

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Scatterplot Dependency vs Copy Number

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Gene's correlated to MAP3K13's dependency profile

Table genes' correlated

Correlated gene dependency Correlation (r) Z_score

Correlation graph for MAP3K13

Biomarkers for dependency on MAP3K13 (ATLANTIS)

Context Dependency dataset Biomarker types Biomarker subset Score transform Top biomarker R^2 P-Value FDR Reports

ShRNA Hairpin level scores

55k shRNA library (v2.4.6)

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98k shRNA library (v2.19.2)

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ShRNA Quality

Plot Table
shRNA ID Gene Symbol Seed1 Sequence Seed2 Sequence Gene Rsquared Seed1 Rsquared Seed2 Rsquared Seeds Rsquared Other Gene Rsquared Total Rsquared Alpha1 Alpha2 Beta Other Gene Symbol

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