NEDD8

Description

neural precursor cell expressed, developmentally down-regulated 8

Summary

None

Location

14q12

External Links
GeneCards , NCBI

Executive summary

  • NEDD8 was screened in 216 cell lines with 3 shRNAs, and 285 cell lines with 5 shRNAs.
  • NEDD8 was a six-sigma dependency in 3 cell lines.
  • The search for "Unbiased" MDPs resulted in the most predictive model for NEDD8 which had an out-of-bag R^2 of 0.24 (FDR 4.39e-02). In addition, this gene had a significant model when searching for the following MDPs: "Unbiased", "Related features".

Dependency profile

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Scatterplots of dependency vs Expression/Copy Number

Scatterplot Dependency vs Expression

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Scatterplot Dependency vs Copy Number

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Gene's correlated to NEDD8's dependency profile

Table genes' correlated

Correlated gene dependency Correlation (r) Z_score

Correlation graph for NEDD8

Biomarkers for dependency on NEDD8 (ATLANTIS)

Context Dependency dataset Biomarker types Biomarker subset Score transform Top biomarker R^2 P-Value FDR Reports

ShRNA Hairpin level scores

55k shRNA library (v2.4.6)

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98k shRNA library (v2.19.2)

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ShRNA Quality

shRNA ID Gene Symbol Seed1 Sequence Seed2 Sequence Gene Rsquared Seed1 Rsquared Seed2 Rsquared Seeds Rsquared Other Gene Rsquared Total Rsquared Alpha1 Alpha2 Beta Other Gene Symbol