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PIK3CA

Description

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

Summary

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers. A pseudogene of this gene has been defined on chromosome 22. [provided by RefSeq, Apr 2016]

Location

3q26.32

External Links
GeneCards , NCBI

Executive summary

  • PIK3CA was screened in 216 cell lines with 7 shRNAs, and 285 cell lines with 13 shRNAs.
  • PIK3CA was a six-sigma dependency in 29 cell lines.
  • The search for "Unbiased" MDPs resulted in the most predictive model for PIK3CA which had an out-of-bag R^2 of 0.43 (FDR 1.89e-02). In addition, this gene had a significant model when searching for the following MDPs: "Unbiased", "Related features", "Mutation driven".
  • PIK3CA was annotated as potentially druggable (either in DGIDB or IUPHAR/BPS Guide to PHARMACOLOGY).

Dependency profile

Histogram Table
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Scatterplots of dependency vs Expression/Copy Number

Scatterplot Dependency vs Expression

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Scatterplot Dependency vs Copy Number

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Gene's correlated to PIK3CA's dependency profile

Table genes' correlated

Correlated gene dependency Correlation (r) Z_score

Correlation graph for PIK3CA

Biomarkers for dependency on PIK3CA (ATLANTIS)

Context Dependency dataset Biomarker types Biomarker subset Score transform Top biomarker R^2 P-Value FDR Reports

ShRNA Hairpin level scores

55k shRNA library (v2.4.6)

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98k shRNA library (v2.19.2)

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ShRNA Quality

Plot Table
shRNA ID Gene Symbol Seed1 Sequence Seed2 Sequence Gene Rsquared Seed1 Rsquared Seed2 Rsquared Seeds Rsquared Other Gene Rsquared Total Rsquared Alpha1 Alpha2 Beta Other Gene Symbol

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