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POLA1

Description

DNA polymerase alpha 1, catalytic subunit

Summary

This gene encodes the catalytic subunit of DNA polymerase, which together with a regulatory and two primase subunits, forms the DNA polymerase alpha complex. The catalytic subunit plays an essential role in the initiation of DNA replication. [provided by RefSeq, Mar 2010]

Location

Xp22.11-p21.3

External Links
GeneCards , NCBI

Executive summary

  • POLA1 was screened in 216 cell lines with 3 shRNAs, and 285 cell lines with 5 shRNAs.
  • The search for "Unbiased" MDPs resulted in the most predictive model for POLA1 which had an out-of-bag R^2 of 0.25 (FDR 4.11e-02). In addition, this gene had a significant model when searching for the following MDPs: "Unbiased".
  • POLA1 was annotated as potentially druggable (either in DGIDB or IUPHAR/BPS Guide to PHARMACOLOGY).

Dependency profile

Histogram Table
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Scatterplots of dependency vs Expression/Copy Number

Scatterplot Dependency vs Expression

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Scatterplot Dependency vs Copy Number

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Gene's correlated to POLA1's dependency profile

Table genes' correlated

Correlated gene dependency Correlation (r) Z_score

Correlation graph for POLA1

Biomarkers for dependency on POLA1 (ATLANTIS)

Context Dependency dataset Biomarker types Biomarker subset Score transform Top biomarker R^2 P-Value FDR Reports

ShRNA Hairpin level scores

55k shRNA library (v2.4.6)

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98k shRNA library (v2.19.2)

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ShRNA Quality

Plot Table
shRNA ID Gene Symbol Seed1 Sequence Seed2 Sequence Gene Rsquared Seed1 Rsquared Seed2 Rsquared Seeds Rsquared Other Gene Rsquared Total Rsquared Alpha1 Alpha2 Beta Other Gene Symbol

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