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POLE2

Description

DNA polymerase epsilon 2, accessory subunit

Summary

DNA polymerase epsilon, which is involved in DNA repair and replication, is composed of a large catalytic subunit and a small accessory subunit. The protein encoded by this gene represents the small subunit (B). Defects in this gene have been linked to colorectal cancer and to combined immunodeficiency. [provided by RefSeq, Jan 2017]

Location

14q21.3

External Links
GeneCards , NCBI

Executive summary

  • POLE2 was screened in 216 cell lines with 5 shRNAs, and 285 cell lines with 5 shRNAs.
  • The search for "CYCLOPS" MDPs resulted in the most predictive model for POLE2 which had an out-of-bag R^2 of 0.094 (FDR 4.99e-02). In addition, this gene had a significant model when searching for the following MDPs: "CYCLOPS".

Dependency profile

Histogram Table
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Scatterplots of dependency vs Expression/Copy Number

Scatterplot Dependency vs Expression

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Scatterplot Dependency vs Copy Number

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Gene's correlated to POLE2's dependency profile

Table genes' correlated

Correlated gene dependency Correlation (r) Z_score

Correlation graph for POLE2

Biomarkers for dependency on POLE2 (ATLANTIS)

Context Dependency dataset Biomarker types Biomarker subset Score transform Top biomarker R^2 P-Value FDR Reports

ShRNA Hairpin level scores

55k shRNA library (v2.4.6)

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98k shRNA library (v2.19.2)

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ShRNA Quality

Plot Table
shRNA ID Gene Symbol Seed1 Sequence Seed2 Sequence Gene Rsquared Seed1 Rsquared Seed2 Rsquared Seeds Rsquared Other Gene Rsquared Total Rsquared Alpha1 Alpha2 Beta Other Gene Symbol

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